Advanced imaging technology for studying tiny particles in medicine
Official title: ONI NanoImager
Funded at Children's Hospital of Los Angeles · NIH-11103001 · Data updated 2026-11-12
This study is using a special imaging tool to take a closer look at tiny particles that can help improve vaccines and treatments for patients, making them more effective and reliable.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $333,128 |
| NIH project number | 1S10OD038280-01 |
| Project ID | NIH-11103001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include patients with conditions that could be treated or diagnosed using advanced therapies involving extracellular vesicles.
✕Less likely to help
Patients with conditions unrelated to the therapeutic applications of extracellular vesicles or lipid nanoparticles may not receive any benefit from this research.
What this research studies
This research focuses on acquiring a cutting-edge imaging device called the ONI Nanoimager to enhance the study of extracellular vesicles (EVs) and lipid nanoparticles (LNPs) at Children's Hospital Los Angeles. By utilizing a technique known as direct Stochastic Optical Reconstruction Microscopy (dSTORM), the Nanoimager allows researchers to visualize these tiny particles at a resolution of 20nm, which is crucial for understanding their structure and function. This advanced imaging capability aims to improve the quality control and reproducibility of therapeutic applications involving EVs and LNPs, such as vaccine development and biomarker discovery. Patients may benefit from the insights gained through this research, which could lead to more effective treatments and therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and vaccines for various medical conditions through better understanding and utilization of extracellular vesicles.
How similar studies have gone: Other research has shown success with similar imaging techniques, indicating a promising potential for breakthroughs in understanding and utilizing extracellular vesicles.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Neviani, Paolo — Children's Hospital of Los Angeles
- Study coordinator: Neviani, Paolo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.