Advanced imaging techniques to locate biomolecules in cells with high precision
Single molecule localization microscopy via angstrom-scale three-dimensional imaging of electron spin labels
This study is working on a new imaging technology that can see tiny details inside cells, helping us understand how proteins and other important parts are organized, which could eventually lead to better ways to diagnose and treat diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10922753 on NIH RePORTER |
What this research studies
This research focuses on developing a groundbreaking imaging technology that can pinpoint the three-dimensional locations of biomolecules within cells at an unprecedented resolution of angstroms. By utilizing a magnetic resonance force microscope, the study aims to detect individual electron spins, allowing for detailed insights into the organization and architecture of proteins and other cellular components. This innovative approach could lead to significant advancements in our understanding of cellular processes and disease mechanisms. Patients may benefit indirectly through improved diagnostic and therapeutic strategies derived from enhanced biological insights.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with diseases related to cellular dysfunction, such as cancer or neurodegenerative disorders.
Not a fit: Patients with conditions unrelated to cellular processes or those not requiring advanced imaging techniques may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostics and targeted therapies for various diseases by providing deeper insights into cellular functions.
How similar studies have performed: While super-resolution microscopy has shown significant success in biological research, the specific approach of angstrom-scale imaging using electron spin labels is relatively novel and has not been extensively tested.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Marohn, John a — Cornell University
- Study coordinator: Marohn, John a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.