Advanced imaging techniques for studying small biomolecules in cells
Official title: Super-sensitive vibrational imaging by synergic development of instruments and probes
Funded at Boston University (Charles River Campus) · NIH-11005324 · Data updated 2026-11-12
This study is working on new ways to take clearer pictures of tiny molecules inside cells, which could help us understand diseases better and improve how we diagnose and monitor treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2024 |
| Project end | December 21, 2027 |
| Funding year | 2025 |
| Award (this year) | $603,846 |
| NIH project number | 5R01EB035429-02 |
| Project ID | NIH-11005324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions that involve small biomolecules, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with conditions that do not involve small biomolecules or those who are not undergoing imaging procedures may not receive benefit from this research.
What this research studies
This research focuses on improving imaging methods to better visualize small biomolecules within cells, addressing limitations of current fluorescence microscopy. By utilizing stimulated Raman scattering (SRS) microscopy, the project aims to enhance chemical sensitivity and provide detailed information about molecular structures and their interactions. The approach involves developing new probes and instruments that can detect low concentrations of important analytes, which could lead to breakthroughs in understanding cellular processes and disease mechanisms. Patients may benefit from advancements in diagnostics and treatment monitoring through improved imaging technologies.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and sensitive imaging techniques that enhance disease diagnosis and treatment monitoring.
How similar studies have gone: Other research has shown promise with similar imaging techniques, indicating potential for significant advancements in the field.
Where this research is happening
-
Boston University (Charles River Campus)
Boston, United States Active
Researchers
- Principal investigator: Cheng, Ji-Xin — Boston University (Charles River Campus)
- Study coordinator: Cheng, Ji-Xin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.