Advanced imaging techniques for studying gene delivery in the nervous system
Official title: Super-resolved multiphoton microscopy with dual output ultrafast laser
Funded at Massachusetts General Hospital · NIH-11146749 · Data updated 2026-11-12
This study is looking at new ways to see how special viruses called AAV vectors work with nerve cells, which could help us find better treatments for brain diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $146,621 |
| NIH project number | 5K25EB032864-03 |
| Project ID | NIH-11146749 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital or acquired neurological diseases that may benefit from gene therapy.
✕Less likely to help
Patients with conditions unrelated to the nervous system or those who do not qualify for gene therapy may not benefit from this research.
What this research studies
This research focuses on improving imaging methods to visualize how gene delivery systems, specifically adeno-associated virus (AAV) vectors, interact with cells in the nervous system. By utilizing advanced two-photon excitation microscopy combined with stimulated emission depletion techniques, the project aims to achieve high-resolution imaging of nanoscale processes in living tissues. This could enhance our understanding of how these viral vectors can be used to treat various neurological diseases. The research will involve both laboratory-based techniques and potential applications in living animal models.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for neurological conditions, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for studying cellular processes, indicating potential success for this novel approach.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Coto Hernandez, Ivan — Massachusetts General Hospital
- Study coordinator: Coto Hernandez, Ivan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.