Advanced imaging techniques for studying biological samples at the molecular level
Ultra-stable, photon-efficient cryogenic super-resolution fluorescence imaging for visualizing vitrified biological samples with molecular-scale resolution
This study is working on new ways to take super-detailed pictures of tiny structures in our cells, which could help us understand how they work and lead to better treatments for diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10707375 on NIH RePORTER |
What this research studies
This research focuses on developing new imaging methods that combine cryogenic electron microscopy and super-resolution fluorescence techniques to visualize biological samples with unprecedented detail. By improving the resolution to below 3 nanometers, the project aims to enhance our understanding of macromolecular assemblies and their functions within cells. Patients may benefit from insights gained into cellular processes that could lead to new treatments or therapies for various diseases. The approach involves creating ultra-stable imaging techniques that can capture the intricate structures of biological specimens at cryogenic temperatures.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular dysfunction or diseases that involve macromolecular processes.
Not a fit: Patients with conditions unrelated to cellular processes or those not requiring advanced imaging techniques may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular functions and the development of targeted therapies for diseases.
How similar studies have performed: Other research has shown success with advanced imaging techniques, but this specific approach aims to achieve a novel level of resolution that has not been extensively tested.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Pertsinidis, Alexandros — Sloan-Kettering Inst Can Research
- Study coordinator: Pertsinidis, Alexandros
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.