Advanced imaging techniques for observing multiple molecules in live cells
Official title: Super-Multiplexed Molecular Sensing in Live Cells
Funded at Emory University · NIH-11223084 · Data updated 2026-11-12
This study is working on new ways to take pictures of different molecules inside living cells all at once, which could help us better understand how cells behave and improve treatments for patients with various conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 21, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $254,244 |
| NIH project number | 7R01GM151093-03 |
| Project ID | NIH-11223084 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that involve complex cellular dynamics, such as cancer or metabolic disorders.
✕Less likely to help
Patients with stable, non-dynamic conditions may not receive significant benefits from this research.
What this research studies
This research focuses on developing innovative imaging methods to visualize many different molecules within live cells simultaneously. By overcoming limitations of traditional fluorescence microscopy, the project aims to create new vibrational probes that can detect various cellular analytes, including reactive species and metal ions, in real-time. The approach utilizes advanced techniques like Stimulated Raman Scattering (SRS) to provide detailed insights into dynamic biological processes. Patients may benefit from improved understanding of cellular behaviors related to their conditions through enhanced imaging capabilities.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular processes, potentially improving diagnosis and treatment strategies for various diseases.
How similar studies have gone: While the use of advanced imaging techniques like SRS is gaining traction, this specific approach to super-multiplexed sensing in live cells is relatively novel and has not been extensively tested.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Buccella, Daniela — Emory University
- Study coordinator: Buccella, Daniela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.