Advanced imaging techniques for diagnosing corneal diseases
Official title: High-throughput optical coherence microscopy for diagnostic evaluation of corneal disease
Funded at Oregon Health & Science University · NIH-11023143 · Data updated 2026-11-12
This study is working on a new way to take super-clear pictures of the cornea, which is important for helping eye doctors spot and treat different eye problems, especially infections that are hard to see right now.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $192,500 |
| NIH project number | 5R21EY035797-02 |
| Project ID | NIH-11023143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing corneal diseases such as infectious keratitis or keratoconus.
✕Less likely to help
Patients with corneal conditions that do not involve infectious agents or structural abnormalities may not benefit from this research.
What this research studies
This research focuses on enhancing optical coherence tomography (OCT) to achieve ultrahigh-resolution imaging of the cornea, which is crucial for diagnosing various corneal diseases. By developing a new microscopy technique that utilizes short-wavelength light sources, the researchers aim to improve the visualization of microscopic structures within the cornea. This method promises faster scan times and the ability to detect pathogens that are currently difficult to visualize, such as bacteria causing infectious keratitis. The goal is to provide ophthalmologists with better diagnostic tools to guide treatment decisions for patients with corneal disorders.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and improved treatment options for patients suffering from corneal diseases.
How similar studies have gone: Previous studies have shown success with OCT imaging techniques, but this approach aims to push the boundaries of resolution and diagnostic capability, making it a novel endeavor.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Jian, Yifan — Oregon Health & Science University
- Study coordinator: Jian, Yifan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.