Advanced imaging techniques for analyzing proteins in cells and tissues
Official title: Next-generation spatial -omics: High-throughput, single-molecule proteomic imaging with subcellular resolution
Funded at California Institute of Technology · NIH-10930833 · Data updated 2026-11-12
This study is exploring new ways to take detailed pictures of proteins in cells, which could help us understand how they work and how diseases develop, ultimately leading to better tests and treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 18, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,223,891 |
| NIH project number | 5R01MH136394-02 |
| Project ID | NIH-10930833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with complex diseases where protein signaling plays a critical role, such as cancer or neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to protein function or those who do not have access to advanced diagnostic facilities may not receive benefits from this research.
What this research studies
This research focuses on developing innovative methods for high-throughput imaging of proteins at a single-molecule level within cells and tissues. By utilizing advanced spatial-omics techniques, the project aims to create detailed maps of protein distribution and function, which are crucial for understanding cellular processes and disease mechanisms. Patients may benefit from this research as it could lead to improved diagnostics and targeted therapies based on a better understanding of protein behavior in various conditions.
Why it matters
Potential benefit: If successful, this research could enhance the precision of disease diagnosis and treatment by providing deeper insights into protein functions and interactions.
How similar studies have gone: Other research has shown promising results using advanced proteomic techniques, indicating that this approach has the potential to yield significant breakthroughs in understanding cellular functions.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Roukes, Michael L — California Institute of Technology
- Study coordinator: Roukes, Michael L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.