Advanced Imaging for Tissue Diagnosis
Dynamic µOCT for cellular tissue phenotyping
This project is creating a new way to look at living cells and tissues in detail to help doctors understand health and disease better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11113799 on NIH RePORTER |
What this research studies
Current methods for examining cells and tissues often require the tissue to be removed and are static, meaning they don't show how cells are actively working. This new imaging technique, called µOCT, aims to capture the dynamic activity of living cells at a very high resolution. By taking multiple images quickly, it can reveal new information about how cells function and interact within tissues. This could provide a more complete picture of tissue health than what is currently available.
Who could benefit from this research
Good fit: Patients who might benefit from more detailed and dynamic imaging of their tissues for diagnostic purposes could be future candidates for technologies developed from this work.
Not a fit: Patients whose conditions do not involve tissue phenotyping or who require immediate, established diagnostic methods may not directly benefit from this foundational technology development.
Why it matters
Potential benefit: If successful, this technology could lead to more accurate and less invasive ways to diagnose diseases by observing living tissue activity.
How similar studies have performed: This project builds on a new field of coherence-gated imaging, but the specific µOCT technology and its dynamic signal analysis are novel and still being explored.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Tearney, Guillermo J — Massachusetts General Hospital
- Study coordinator: Tearney, Guillermo J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.