Advanced Imaging for Mitral Valve Prolapse
PET/MRI imaging of mitral valve prolapse
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11092335
This research uses special PET/MRI scans to better understand the link between inflammation and heart rhythm problems in people with mitral valve prolapse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11092335 on ClinicalTrials.gov |
What this research studies
Mitral valve prolapse (MVP) is a common heart condition that can sometimes lead to serious complications like heart failure and dangerous heart rhythms. We know that scarring in the heart muscle is often seen in people with MVP who experience these rhythm issues. Our early findings suggest that inflammation might happen before this scarring develops. This project will use advanced PET/MRI scans, which can show both inflammation and scarring, to explore how these changes relate to the severity of MVP and the risk of heart rhythm problems.
Who could benefit from this research
Good fit: Patients with mitral valve prolapse, especially those with or at risk for heart rhythm abnormalities, would be ideal candidates for this type of research.
Not a fit: Patients without mitral valve prolapse or those whose condition is not related to inflammation or scarring may not directly benefit from this specific imaging approach.
Why it matters
Potential benefit: If successful, this work could help doctors identify patients with mitral valve prolapse who are at higher risk for serious heart rhythm problems, allowing for earlier or more targeted care.
How similar studies have performed: While cardiac MRI has shown success in detecting scarring in MVP, this project explores the novel use of PET/MRI to specifically identify inflammation that may precede scarring and contribute to arrhythmias.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRIVIERI, MARIA GIOVANNA — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: TRIVIERI, MARIA GIOVANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Barlows Syndrome