Advanced imaging and computer tools for small cell lung cancer
Advanced Imaging and Computational Approaches
Researchers are building powerful microscopes and data tools to find out why small cell lung cancer sometimes responds to treatment and sometimes becomes resistant for people with the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11171421 on NIH RePORTER |
What this research studies
The team will use very high-resolution, multi-color microscopes along with live-cell single-molecule tracking and time-lapse imaging of cells and 3D tumoroid models to watch how cancer cells behave. They will combine those images with sequencing and mass spectrometry data and create automated analysis pipelines to extract meaningful patterns. The core will make interactive web tools and share data and analysis methods so other scientists can explore the findings. Training materials will be created so labs can use the same imaging and computational approaches.
Who could benefit from this research
Good fit: People with small cell lung cancer, particularly those whose tumors are not responding to current treatments or who might contribute tumor samples, would be most relevant to this work.
Not a fit: Patients without small cell lung cancer or those needing immediate changes to their care are unlikely to gain direct, immediate benefits from this core project.
Why it matters
Potential benefit: If successful, this work could reveal why some SCLC tumors stop responding to therapies and point to new treatment targets or tests to guide therapy choices.
How similar studies have performed: Similar advanced imaging and integrated data-analysis approaches have helped uncover resistance mechanisms in other cancers, so the methods are promising though their application to SCLC is still developing.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Fenyo, David — New York University School of Medicine
- Study coordinator: Fenyo, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.