Advanced heart MRI to find early left‑ventricle changes
Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular Disease
Using advanced MRI image analysis to find early heart muscle changes in adults and help predict future heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11062350 on NIH RePORTER |
What this research studies
You would have a cardiac MRI whose images are analyzed with computer methods that read pixel patterns (radiomics) and measure how the heart muscle moves (strain and torsion). Those image features are compared with medical history and follow‑up information to find patterns linked to future heart disease. The goal is to detect subtle left‑ventricle changes before standard measures like ejection fraction show problems. Findings could help doctors identify people at higher risk earlier so they can get closer monitoring or treatments.
Who could benefit from this research
Good fit: Ideal candidates are adults (age 21 and over), including older adults and African American participants, who can undergo cardiac MRI and are willing to share follow‑up health information.
Not a fit: People who cannot have an MRI (for example due to incompatible implants), or those with advanced symptomatic heart disease already receiving definitive treatment, are unlikely to gain direct benefit from participation.
Why it matters
Potential benefit: If successful, this work could help identify people at risk for heart disease earlier than standard tests, enabling earlier monitoring or treatment.
How similar studies have performed: Related research on MRI strain and radiomic texture has shown promising signals for detecting disease, but combining these methods for population risk prediction is still emerging.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Tsao, Connie — Beth Israel Deaconess Medical Center
- Study coordinator: Tsao, Connie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.