Advanced brain scans to map tiny nerve fibers and tissue structure
Developing next-generation imaging technologies for in-vivo mesoscale diffusion MRI and microstructure imaging
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11247100
This project develops much faster, clearer MRI techniques to show tiny brain fibers and tissue structure for people who need precise brain imaging, such as patients considered for deep brain stimulation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11247100 on ClinicalTrials.gov |
What this research studies
The team is building new MRI acquisition and processing methods to boost signal, reduce motion problems, and cut scan time dramatically (aiming for up to about 25× faster effective imaging). They will combine high-resolution, high b-value diffusion imaging with improved hardware and software to better reveal small deep brain fibers and microstructural tissue features. The proposal targets common image issues like distortion, blurring, slab-boundary striping, and low signal-to-noise that currently prevent clinical use. Methods will be tested in realistic in-vivo scans and translated into protocols for use at the hospital.
Who could benefit from this research
Good fit: Ideal candidates are adults who need high-detail brain imaging or are being evaluated for procedures like deep brain stimulation and who can safely undergo MRI.
Not a fit: People with MRI contraindications (for example certain metal implants or pacemakers) or whose conditions do not involve small-scale brain pathways may not benefit.
Why it matters
Potential benefit: Could let doctors see and track tiny brain pathways and tissue changes earlier and with shorter, more comfortable scans.
How similar studies have performed: While advanced diffusion MRI methods have improved microstructure imaging in research settings, achieving motion-robust, mesoscale-resolution and high b-value imaging in short clinical scan times remains largely novel.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, FUYIXUE — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: WANG, FUYIXUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.