Adolescent Airway Health: How Hormones and Chemicals Affect Breathing
TIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway Health
This project looks at how certain chemicals and hormones might affect breathing and lung health in teenagers, especially focusing on differences between boys and girls.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11101353 on NIH RePORTER |
What this research studies
The previous TIDES studies showed that common environmental chemicals like phthalates and bisphenols can affect development in babies and young children by changing hormone levels. This new phase, TIDES III, focuses on how these chemicals and hormones might specifically impact airway health in adolescents, where breathing problems like asthma often become more common in girls. Researchers will invite 500 adolescents who participated in earlier TIDES studies for two new visits at ages 12 and 14. During these visits, they will collect urine and blood samples to measure chemical exposures and hormone levels, and also check lung function using questionnaires and breathing tests. The goal is to understand why airway diseases affect girls more as they get older and how environmental factors and hormones play a role.
Who could benefit from this research
Good fit: This project involves adolescents who previously participated in The Infant Development and Environment Study (TIDES) and are now between 12 and 14 years old.
Not a fit: Patients who have not participated in the earlier TIDES studies would not be eligible for direct involvement in this specific follow-up.
Why it matters
Potential benefit: If successful, this work could help us understand why airway diseases affect adolescent girls more and lead to better ways to prevent or treat these conditions.
How similar studies have performed: Previous phases of the TIDES project have already shown links between prenatal chemical exposure and developmental outcomes, providing a strong foundation for this continued work.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Sathyanarayana, Sheela — Seattle Children's Hospital
- Study coordinator: Sathyanarayana, Sheela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.