ADME/Formulation Core supports drug development
Official title: ADME/FORMULATION Core
Funded at Scripps Research Institute, the · NIH-11542049 · Data updated 2026-11-12
A research team is building a core unit to study how potential drugs are absorbed, distributed, metabolized, and eliminated, and to develop stable formulations to support testing in humans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 16, 2022 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,612,976 |
| NIH project number | 4U19AI171443-02 |
| Project ID | NIH-11542049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals who could benefit from future therapies developed from CAMPP-related programs and who may participate in future trials or contribute samples for translational studies.
✕Less likely to help
This grant itself does not enroll patients; however, later studies using compounds profiled by this core may impact patient care.
What this research studies
This grant funds a dedicated ADME and formulation core that provides drug profiling, PK data, and safety testing to guide optimization of hit compounds from early screening to preclinical candidate selection. It supports in vitro and in vivo studies, including absorption, metabolism, distribution, elimination, formulation development, and safety pharmacology, with a focus on cardiotoxicity and other toxicology endpoints. The work is integrated across CAMPP partners to standardize profiling and accelerate translation toward IND-enabling studies. The core helps researchers at Scripps and collaborating institutions by delivering consistent data and capabilities that inform decisions about which compounds to advance.
Why it matters
Potential benefit: If successful, patients could benefit from faster, safer progression of promising drug candidates toward human testing.
How similar studies have gone: Similar ADME/formulation cores have supported successful lead optimization in translational programs, though specific outcomes depend on later-stage development.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Joseph, Sean B. — Scripps Research Institute, the
- Study coordinator: Joseph, Sean B.
Related research
Other NIH-funded projects on the same topics.
-
The Participant Center helps people join and stay in a nationwide health study
A nationwide program to support people in joining, contributing biosamples, and staying connected to a large health study in the United States.
-
Data Sharing and Bioinformatics Core for Viral Systems Biology
A center-led effort to manage, share, and interpret large viral systems biology data using open tools and a community-friendly portal.
-
Germline-targeted HIV vaccines using membrane liposome tech to trigger bnAbs
A new HIV vaccine approach aims to spark broadly neutralizing antibodies by showing MPER on membranes, tested in models and early studies to guide future human trials.
-
Antivirals for hemorrhagic fever viruses like LASV, SFTSV, and EBOV
A multi-institutional effort to find and validate antiviral compounds that block key viral proteins from LASV, SFTSV, and EBOV to help people at risk from serious hemorrhagic fevers.
-
Developing new antivirals for flaviviruses
A research team is working to create oral antiviral drugs targeting flaviviruses to treat infections that affect millions of people.
-
CoV inhibitors targeting non-enzymatic SARS-CoV-2 components
A multicenter research effort seeks antiviral ideas that block SARS-CoV-2 parts that don’t work through traditional enzymes, aiming to help people affected by COVID-19.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.