Adipose tissue failure after burn in older adults and aged mice
Official title: Adverse outcomes of aged mice are associated with adipose tissue failure after burn
Funded at Hamilton Health Sciences Corporation · NIH-11393003 · Data updated 2026-11-12
A study explores why older adults have worse outcomes after burns by looking at how fat tissue behaves and fails after injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hamilton Health Sciences Corporation NIH-funded |
| Lab location | 1 site (Hamilton, Canada) |
| Project start | September 30, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $334,679 |
| NIH project number | 5R01AG080040-04 |
| Project ID | NIH-11393003 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older who have suffered burns, and appropriate aged-matched controls or aged mice for comparative studies.
✕Less likely to help
Healthy young adults without burns, or non-human subjects, are unlikely to benefit directly.
What this research studies
This project compares how adipose tissue responds to burns in older adults and in aged mice to uncover why elderly patients have higher morbidity and mortality. It focuses on adipose tissue changes, mitochondrial function, NAD levels, and the browning process, which are important for immune and metabolic responses after injury. By examining autocrine signaling and how brown fat activity differs with age, the study aims to identify targets that could improve recovery after burns in older patients. Results could inform new care strategies that support metabolic and immune health during burn treatment in the elderly.
Why it matters
Potential benefit: If successful, findings could guide therapies to boost adipose tissue function and improve survival and recovery for older burn patients.
How similar studies have gone: Preliminary work in older adults and aged mice has shown adipose tissue and mitochondrial differences after burn, supporting further investigation.
Where this research is happening
-
Hamilton Health Sciences Corporation
Hamilton, Canada Active
Researchers
- Principal investigator: Jeschke, Marc Gerhard — Hamilton Health Sciences Corporation
- Study coordinator: Jeschke, Marc Gerhard
Related research
Other NIH-funded projects on the same topics.
-
How age-related failure of fat tissue makes burns harder to recover from
This project tests whether age-related breakdown of fat tissue and low cellular energy make burns more dangerous for older adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.