Addressing how C-F bonds affect brain health in Alzheimer’s disease
Official title: Addressing C-F bonds and amyloid-formation in biological systems
Funded at University of Texas El Paso · NIH-11356942 · Data updated 2026-11-12
A small NIH grant explores how fluorinated chemicals may contribute to brain changes seen in Alzheimer’s disease and what that could mean for preventing or slowing symptoms.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas El Paso NIH-funded |
| Lab location | 1 site (El Paso, United States) |
| Project start | June 11, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $138,730 |
| NIH project number | 1R03NS148908-01 |
| Project ID | NIH-11356942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer’s disease/dementia or at-risk populations who might be exposed to fluorinated chemicals could benefit from future applications of this work.
✕Less likely to help
Healthy individuals without exposure concerns may not directly benefit from this early-stage study.
What this research studies
This project looks at how certain fluorinated compounds may interact with proteins in the brain and alter cellular processes that relate to dementia. Using both lab experiments and computational approaches, researchers are mapping how C-F bond-containing chemicals disrupt biomolecules and contribute to oxidative stress and inflammation. The goal is to create a clearer picture of how exposure could influence neurodegenerative pathways relevant to Alzheimer’s dementia. If findings translate to humans, this could guide safer chemical design and strategies to protect brain health.
Why it matters
Potential benefit: Results could inform safer chemical practices and future therapies to reduce chemical-related brain damage in people with Alzheimer’s.
How similar studies have gone: Preliminary data show that fluorinated chemicals can affect protein structures and cellular pathways, suggesting potential relevance to neurodegeneration.
Where this research is happening
-
University of Texas El Paso
El Paso, United States Active
Researchers
- Principal investigator: Narayan, Mahesh — University of Texas El Paso
- Study coordinator: Narayan, Mahesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.