Activation of deep crypt secretory cells in colonic inflammation (a pathway linked to colitis)
Official title: Activation of deep crypt secretory cells in colonic inflammation
Funded at Stanford University · NIH-11581866 · Data updated 2026-11-12
A research project at Stanford is studying a rare colonic cell type called deep crypt secretory cells to understand how they influence inflammation and healing in inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $527,691 |
| NIH project number | 7R01DK140323-03 |
| Project ID | NIH-11581866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with inflammatory bowel disease or colitis where colonic epithelial biology is relevant.
✕Less likely to help
This research is basic science in model systems and may not directly benefit a patient in the short term.
What this research studies
This project explores how a specific group of cells at the base of colon glands respond during colitis and tissue repair. Researchers will examine how immune signals change DCS cells and whether these cells adopt an activated state that affects inflammation and defense. The work aims to define what activated DCS cells do in the colon and how they contribute to recovery after inflammation. The study will use laboratory models to test how impaired DCS responses impact disease severity and healing.
Why it matters
Potential benefit: Understanding DCS cells could lead to new ways to reduce inflammation and promote healing in inflammatory bowel disease.
How similar studies have gone: Prior work shows immune signals can alter epithelial cell behavior, but the specific role of DCS cells in colitis is still being defined.
Where this research is happening
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Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Schumacher, Michael Andrew — Stanford University
- Study coordinator: Schumacher, Michael Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.