Activating specific signaling pathways in dopamine neurons to understand cocaine effects
Official title: Selective real-time activation of ERK1/2 signaling in dopamine neurons
Funded at Drexel University · NIH-10706605 · Data updated 2026-11-12
This study is looking at how cocaine impacts brain cells that produce dopamine, using special techniques to better understand the signals involved, with the goal of finding new ways to help people struggling with cocaine addiction.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $189,375 |
| NIH project number | 5R21DA057054-02 |
| Project ID | NIH-10706605 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of cocaine use or those diagnosed with cocaine use disorders.
✕Less likely to help
Patients who do not use cocaine or have no history of substance abuse may not benefit from this research.
What this research studies
This research investigates how cocaine affects dopamine neurons by focusing on a specific signaling pathway known as ERK1/2. The study uses advanced techniques to control this signaling in real-time within the brain, specifically targeting dopamine neurons in transgenic rats. By understanding these mechanisms, the research aims to identify new therapeutic strategies for treating cocaine use disorders, which currently lack effective treatments. The approach combines genetic engineering and light activation to precisely manipulate cellular responses.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for individuals struggling with cocaine addiction.
How similar studies have gone: While the specific approach of using light-activated signaling in dopamine neurons is novel, similar studies have shown promise in understanding addiction mechanisms.
Where this research is happening
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Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Mortensen, Ole Valente — Drexel University
- Study coordinator: Mortensen, Ole Valente
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.