Activating brain lymphatics to explore new treatments for Alzheimer's disease
Official title: Multiplex meningeal lymphatic activation for Alzheimer’s disease
Funded at University of Southern California · NIH-11163459 · Data updated 2026-11-12
This study is looking at new ways to help people with Alzheimer's disease by boosting the brain's lymphatic system, using methods like special proteins, gene therapy, and stem cells, to see if these can improve thinking and memory skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R21AG089268-02 |
| Project ID | NIH-11163459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's disease or those at risk due to craniosynostosis.
✕Less likely to help
Patients with Alzheimer's disease who do not have any craniosynostosis-related conditions may not benefit from this research.
What this research studies
This research investigates how activating the brain's lymphatic system may provide new therapeutic strategies for Alzheimer's disease (AD). The team will explore three innovative methods to enhance lymphatic function, including delivering a specific protein, injecting a gene therapy, and implanting stem cells. By understanding the relationship between craniosynostosis, a skull disorder, and AD, the researchers aim to uncover potential risk factors and treatment pathways. Patients may benefit from these approaches if they demonstrate effectiveness in improving cognitive function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with Alzheimer's disease.
How similar studies have gone: While the activation of brain lymphatics is a relatively novel approach, preliminary studies have shown promise in related areas, suggesting potential for success.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Chen, Jianfu — University of Southern California
- Study coordinator: Chen, Jianfu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.