Activating a protein that helps protect against age-related diseases
Small molecule approach to activate human SIRT5
['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11009920
This study is looking at a protein called SIRT5 that helps keep your heart and brain healthy, especially when you're under stress, and they're testing small compounds that could boost SIRT5's activity to help create new treatments for age-related health issues like heart disease and memory problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11009920 on ClinicalTrials.gov |
What this research studies
This research focuses on a protein called SIRT5, which plays a crucial role in maintaining heart health and brain function, especially under stress. The team is investigating small molecules that can enhance the activity of SIRT5, potentially mimicking the benefits of calorie restriction. By understanding how to activate SIRT5 effectively, the research aims to develop new treatments for age-related disorders such as cardiovascular diseases and neurodegenerative conditions. Patients may benefit from therapies that improve their health as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for age-related diseases, particularly those with cardiovascular or neurodegenerative conditions.
Not a fit: Patients with acute or non-age-related diseases may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or manage age-related diseases.
How similar studies have performed: Other research has shown promise in activating sirtuins for health benefits, suggesting this approach could be effective.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CEN, YANA — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: CEN, YANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder, age related human disease