Accelerating antibody discovery using memory B cells
Official title: Scaling function-first antibody discovery leveraging memory B cells
Funded at Partillion Bioscience Corporation · NIH-11310825 · Data updated 2026-11-12
A new program aims to speed up finding useful monoclonal antibodies by leveraging memory B cells with innovative tools to sort and test many cells at once.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Partillion Bioscience Corporation NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,000,000 |
| NIH project number | 5R44AI193415-02 |
| Project ID | NIH-11310825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Candidates for future antibody therapies or patients involved in related clinical trials where antibody treatments are relevant.
✕Less likely to help
Patients not needing antibody-based therapies or those whose condition is not driven by the targeted antigens may not directly benefit.
What this research studies
This project from Partillion Bioscience focuses on making antibody discovery faster and cheaper by using special hydrogel particles to sort single B cells and antibody-secreting cells. It plans to increase throughput tenfold and enable advanced functional tests like checking how antibodies bind to targets on cell surfaces and trigger receptor activity. The approach uses common lab equipment, making high-quality antibody screening more accessible to many researchers and settings. If successful, it could broaden the range of antibodies discovered and reduce wasted sequences, speeding potential therapies to patients.
Why it matters
Potential benefit: If successful, patients could benefit from faster development of targeted antibody therapies with lower costs.
How similar studies have gone: Previous antibody discovery methods are effective but can be costly and slow; this project seeks a scalable improvement with some prior success in microfluidics and single-cell sorting.
Where this research is happening
-
Partillion Bioscience Corporation
Los Angeles, United States Active
Researchers
- Principal investigator: De Rutte, Joseph — Partillion Bioscience Corporation
- Study coordinator: De Rutte, Joseph
Related research
Other NIH-funded projects on the same topics.
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Nanovial tools to map how single cells talk to each other at scale
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-
Multiplexed antibody discovery using single-cell Nanovials
A patient-friendly look at a new method to speed up creating monoclonal antibodies by analyzing individual antibody-secreting cells more efficiently.
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Improving the discovery of effective antibody therapies
This study is working on a faster and easier way to find important proteins called monoclonal antibodies, which help create better treatments for patients, so you can get more effective therapies more quickly and at a lower cost.
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Exploring how antibody sequences work at the single-cell level using new technology
This study is testing a new technology that helps scientists look closely at how individual antibodies work, which could lead to quicker and better treatments for diseases like autoimmune disorders and cancer, ultimately helping patients get the right therapies faster.
-
Using hydrogel microparticles to improve CAR-T cell therapies for cancer treatment
This study is working on improving CAR-T cell therapies for cancer by using special technology to find the best CAR-T cells that can fight tumors, which could lead to better treatments for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.