ACCELERATE: Improving Understanding of Castleman Disease
ACCELERATE: An Efficient and Innovative Natural History Study Addressing Unmet Needs in Castleman Disease
This project aims to gather important information about Castleman disease to help doctors better understand and treat this rare condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11162374 on NIH RePORTER |
What this research studies
Castleman disease is a rare blood disorder that affects about 2,000 people in the US each year, causing enlarged lymph nodes and inflammation. Currently, we don't fully understand what causes it, how best to treat it, or how to tell which treatments will work for which patients. This project is creating an international collection of patient information over time, called a natural history study. By carefully tracking how the disease progresses and how patients respond to different treatments, we hope to find better ways to diagnose and care for those with Castleman disease.
Who could benefit from this research
Good fit: Patients of all ages diagnosed with any form of Castleman disease, including both unicentric and multicentric types, would be ideal candidates for this type of natural history data collection.
Not a fit: Patients who do not have Castleman disease would not directly benefit from this specific research.
Why it matters
Potential benefit: This work could lead to clearer diagnostic guidelines, more effective treatments, and ways to predict which treatments will work best for patients with Castleman disease.
How similar studies have performed: While individual treatments have been tried, systematic evaluations and centralized data collection for Castleman disease are relatively new, making this a novel and much-needed approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Brandstadter, Joshua D. — University of Pennsylvania
- Study coordinator: Brandstadter, Joshua D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.