A vaccine to protect against Cryptococcus in people with AIDS
Mechanisms of vaccine protection against AIDS-associated Cryptococcus infection
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11226113
This research is exploring a new vaccine candidate to protect people with AIDS from life-threatening fungal infections like Cryptococcus meningitis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11226113 on ClinicalTrials.gov |
What this research studies
Invasive fungal infections are a serious concern, especially for individuals with AIDS, as they can lead to conditions like fungal meningitis and are often fatal. Currently, there are very few treatment options and no vaccines available to prevent these infections. Our scientists have identified a promising new vaccine candidate, called HK-fbp1, which has shown broad protection against Cryptococcus and other fungal infections in initial studies. This work aims to understand how this vaccine works to help bring it closer to becoming a new treatment.
Who could benefit from this research
Good fit: This research is ultimately intended to benefit individuals with Acquired Immune Deficiency Syndrome (AIDS) who are vulnerable to fungal infections.
Not a fit: Patients who do not have AIDS or are not at risk for these specific fungal infections may not directly benefit from this particular vaccine.
Why it matters
Potential benefit: If successful, this vaccine could offer a much-needed way to prevent severe fungal infections in people living with AIDS, potentially saving lives.
How similar studies have performed: Previous studies by this team have already shown that the HK-fbp1 vaccine candidate provides significant protection in animal models.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XUE, CHAOYANG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: XUE, CHAOYANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome