A vaccine targeting cancer mutations in Lynch syndrome patients
Lynch Vaccine
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10906212
This study is working on a personalized vaccine for people with Lynch syndrome to help boost their immune system against colorectal cancer and other related cancers by targeting specific changes in their tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10906212 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a vaccine for patients with Lynch syndrome, a genetic condition that increases the risk of colorectal cancer and other malignancies. The approach involves identifying specific mutations in tumors that are common among patients and using these to create a personalized vaccine that enhances the immune response against cancer cells. By leveraging findings from previous trials, the research aims to improve T-cell immunity and reduce cancer burden in affected individuals. The study will utilize advanced genomic sequencing and immunological techniques to identify and validate potential vaccine candidates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lynch syndrome who are at risk for colorectal cancer and other related malignancies.
Not a fit: Patients without Lynch syndrome or those who do not have a history of colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel vaccine that significantly improves cancer treatment outcomes for patients with Lynch syndrome.
How similar studies have performed: Previous research has shown promising results with similar vaccine approaches in enhancing immune responses against cancer mutations, indicating potential for success in this novel application.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIPKIN, STEVEN M — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: LIPKIN, STEVEN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.