A vaccine approach to prevent the spread of HIV in monkeys
Project 1: Immunologic and Virologic Characterization of RhCMV/SIV Vaccine-Mediated SIV Replication Arrest Efficacy
This study is testing a new vaccine made from a special virus that could help protect monkeys from a virus similar to HIV, and by learning how it works, researchers hope to find ways to create effective HIV vaccines for people.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10895456 on NIH RePORTER |
What this research studies
This research investigates a novel vaccine based on a specific strain of rhesus cytomegalovirus that expresses HIV-related antigens. The vaccine aims to elicit strong immune responses that can effectively halt the replication and spread of the simian immunodeficiency virus (SIV) in vaccinated rhesus macaques. By studying the immune mechanisms involved, the research seeks to understand how certain immune cells can maintain viral suppression over time. This could provide insights into developing effective HIV vaccines for humans.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals at high risk for HIV infection or those living with HIV who are seeking innovative treatment options.
Not a fit: Patients who are already on effective antiretroviral therapy and have well-controlled HIV may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to a breakthrough HIV vaccine that significantly reduces the risk of infection and improves immune response in patients.
How similar studies have performed: While this approach is novel, previous studies have shown promise in using viral vectors for vaccine development, indicating potential for success.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Sacha, Jonah B. — Oregon Health & Science University
- Study coordinator: Sacha, Jonah B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.