A trusted database of treatment-relevant cancer DNA changes
Creation of a knowledgebase of high quality assertions of the clinical actionability of somatic variants in cancer
Creating a shared, high-quality resource of tumor DNA changes to help doctors and patients find information that could affect diagnosis and treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11160671 on NIH RePORTER |
What this research studies
As a patient, this project will gather and organize evidence about DNA changes found in tumors and record clear statements about what those changes mean for cancer care. Experts will review and curate the evidence using the CIViC platform and procedures adapted from ClinGen. The team will apply international data standards so the information can be shared and linked with other clinical and research systems. The end result will be an online, searchable knowledgebase that clinicians and researchers can use when interpreting tumor sequencing results.
Who could benefit from this research
Good fit: People with cancer whose tumors have undergone genetic sequencing and who want clearer, evidence-based information about the meaning of specific mutations.
Not a fit: Patients whose tumors have not been genetically tested or who do not have cancer-related genetic changes are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could make it easier to match tumor mutations to possible diagnoses, prognoses, and treatment options.
How similar studies have performed: This effort builds on established resources like ClinGen and CIViC that have shown success in curating germline and variant information, while somatic-focused resources are newer but promising.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Griffith, Malachi — Washington University
- Study coordinator: Griffith, Malachi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.