A treatment that aims to achieve a long-lasting cure for HIV without ongoing medication.
An AAV-mediated functional cure and its impact on the reservoir
['FUNDING_OTHER'] · BOSTON CHILDREN'S HOSPITAL · NIH-10864926
This study is looking at a new way to help people with HIV by using special viruses to deliver treatments that could keep the virus under control for a long time without needing daily medication, and it might give patients a chance for lasting health improvements.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10864926 on ClinicalTrials.gov |
What this research studies
This research investigates the potential for a functional cure for HIV by using adeno-associated viruses (AAV) to deliver broadly neutralizing antibodies and entry inhibitors. The approach is based on successful preliminary results in non-human primates, where long-term expression of these agents has led to sustained viral suppression without the need for antiretroviral therapy. The study aims to enhance the safety and effectiveness of this treatment, while also exploring ways to manage the immune response to the therapy. Patients may benefit from a new treatment option that could lead to long-term remission from HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are seeking alternative treatment options and are willing to participate in clinical trials.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a functional cure for HIV, allowing patients to live without the need for continuous medication.
How similar studies have performed: Other research has shown promising results in similar approaches, particularly in non-human primates, but this specific application in humans is still being explored.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FARZAN, MICHAEL R. — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: FARZAN, MICHAEL R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.