A test to determine if Chagas disease has been cured
Official title: Biomarker-Based Test of Cure for Chagas Disease
Funded at Kephera Diagnostics, LLC · NIH-10920488 · Data updated 2026-11-12
This study is working on a simple blood test to help people know if they are cured of Chagas disease after treatment, making it easier for patients and doctors to track how well the treatment is working.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kephera Diagnostics, LLC NIH-funded |
| Lab location | 1 site (Framingham, UNITED STATES) |
| Project start | July 16, 2019 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,013,849 |
| NIH project number | 5R44AI147973-04 |
| Project ID | NIH-10920488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Chagas disease, particularly those who have undergone treatment and are in the chronic phase of the infection.
✕Less likely to help
Patients who have not been diagnosed with Chagas disease or those who are in the acute phase may not benefit from this research.
What this research studies
This research focuses on developing a biomarker-based test to determine if patients have been cured of Chagas disease, which is caused by the Trypanosoma cruzi parasite. The approach involves measuring specific biological markers in the blood that indicate the presence or absence of the infection. By improving diagnostic capabilities, this research aims to enhance treatment outcomes and monitor the effectiveness of existing therapies, particularly for those who have undergone treatment for chronic Chagas disease.
Why it matters
Potential benefit: If successful, this research could provide a reliable method for confirming the cure of Chagas disease, leading to better management of the condition and improved patient outcomes.
How similar studies have gone: While there have been efforts to improve diagnostics for Chagas disease, this biomarker-based approach is relatively novel and has not been extensively tested in previous research.
Where this research is happening
-
Kephera Diagnostics, LLC
Framingham, United States Active
Researchers
- Principal investigator: Levin, Andrew E. — Kephera Diagnostics, LLC
- Study coordinator: Levin, Andrew E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.