A system to quickly assess the risk of lung failure after trauma
Official title: Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome
Funded at Univ of Maryland, College Park · NIH-10796865 · Data updated 2026-11-12
This study is working on a handy tool that can quickly check for certain proteins in trauma patients to help doctors spot the risk of serious breathing problems early on, so they can start treatment right away if needed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project start | March 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $375,048 |
| NIH project number | 5R61HL167252-02 |
| Project ID | NIH-10796865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced traumatic injuries that may lead to acute respiratory distress syndrome.
✕Less likely to help
Patients who have not experienced trauma or those with pre-existing respiratory conditions may not benefit from this research.
What this research studies
This research focuses on developing a portable diagnostic tool that can quickly measure levels of circulating histones in trauma patients. Histones are proteins that can indicate the risk of developing acute respiratory distress syndrome (ARDS) following a traumatic injury. By detecting these proteins early, healthcare providers can assess a patient's risk for ARDS and potentially initiate life-saving treatments before the condition develops. The tool aims to be used in various settings, including at the site of injury, during transport, or in emergency departments.
Why it matters
Potential benefit: If successful, this research could lead to timely interventions that prevent the onset of ARDS in trauma patients, significantly improving their chances of recovery.
How similar studies have gone: While the approach of using histones as biomarkers is promising, the specific portable diagnostic tool being developed is novel and has not been tested in this context before.
Where this research is happening
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Univ of Maryland, College Park
College Park, United States Active
Researchers
- Principal investigator: White, Ian M — Univ of Maryland, College Park
- Study coordinator: White, Ian M
Related research
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This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.