A system to detect DNA mutations that affect health and disease
MutSensor System: A Set of Highly Sensitive Mutation Reporters to Dissect Genome Stability in Health and Disease
This study is looking at how changes in our DNA happen in human cells and how these changes can lead to diseases like cancer, using a new tool called MutSensor to get better measurements, which could help us understand and fix these mutations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10930104 on NIH RePORTER |
What this research studies
This research focuses on understanding how DNA mutations occur in human cells and their role in diseases like cancer. By developing a new tool called MutSensor, the researchers aim to measure DNA mutation rates with much greater sensitivity than current methods. This innovative approach will allow them to identify the genetic factors that influence mutation frequency across different cell types in the human body. The findings could provide crucial insights into how mutations contribute to various diseases and how they can be repaired.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with conditions related to DNA mutations.
Not a fit: Patients with no known genetic predisposition to mutations or those without a history of related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for diseases caused by DNA mutations, including cancer.
How similar studies have performed: Other research has shown success in using advanced genetic tools to study mutations, making this approach promising yet innovative.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Davoli, Teresa — New York University School of Medicine
- Study coordinator: Davoli, Teresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.