NIH-funded research R01 grant

A system to automatically manage blood sugar levels during unexpected activities and stress.

Official title: Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress

Funded at Illinois Institute of Technology · NIH-10488195 · Data updated 2026-11-12

This study is working on a smart insulin delivery system that automatically adjusts your insulin based on real-time information about your blood sugar, especially when you’re active or feeling stressed, to help make managing diabetes easier and keep you safer.

More Psychological research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionIllinois Institute of Technology
NIH-funded
Lab location1 site (Chicago, United States)
Project startSeptember 12, 2021
Project endJuly 31, 2025
Funding year2022
Award (this year)$502,959
NIH project number5R01DK130049-02
Project IDNIH-10488195 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals with type 1 diabetes who experience challenges in managing their blood glucose levels due to unexpected activities or stress.

Less likely to help

Patients with type 2 diabetes or those who do not experience significant fluctuations in blood sugar due to physical activities or stress may not benefit from this research.

What this research studies

This research aims to develop an advanced artificial pancreas system that can automatically adjust insulin delivery based on real-time data from continuous glucose monitors. It focuses on detecting unplanned physical activities and acute psychological stress, which can significantly impact blood sugar levels in individuals with diabetes. By integrating various data inputs, the system seeks to minimize the need for manual adjustments by users, making diabetes management easier and safer. The goal is to enhance the quality of life for patients by reducing the frequency of dangerous blood sugar fluctuations.

Why it matters

Potential benefit: If successful, this research could lead to improved blood sugar control and a better quality of life for individuals with diabetes.

How similar studies have gone: Previous research has shown promise in developing artificial pancreas systems, but this approach is innovative in its focus on unplanned activities and stress management.

Where this research is happening

  • Illinois Institute of Technology
    Chicago, United States
    Active

Researchers

  • Principal investigator: Cinar, Ali — Illinois Institute of Technology
  • Study coordinator: Cinar, Ali

Related research

Other NIH-funded projects on the same topics.

  • Role of epithelial ROS signaling in stress-related gut dysfunction and colitis risk

    This NIH grant looks at how stress changes the gut lining and its microbes, possibly increasing the risk of inflammatory bowel disease in people who are genetically predisposed.

    NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11361588

  • Understanding how stress affects young people

    This project explores how stress affects young male and female mice to better understand why depression often starts in adolescence and affects girls more than boys.

    NIH research University of Texas El Paso · El Paso, United States · NIH-11105909

  • Understanding how stress affects gut health and IBD risk

    This project explores how psychological stress changes the gut lining and bacteria, which might make some people more likely to develop inflammatory bowel diseases.

    NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11092247

  • How brain stimulation affects emotional responses to stress

    This study is looking at how short-term stress affects our feelings and body responses, and it’s for adults who want to understand how brain stimulation can change how we react to stress.

    NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10948563

  • Investigating how psychological stress affects young male and female mice

    This study looks at how stress affects young male and female mice and how it might lead to feelings similar to depression, helping us understand the differences in how boys and girls handle stress during their growing years.

    NIH research University of Texas El Paso · El Paso, United States · NIH-10874565

  • Mobile app to help family caregivers in Thailand manage distress

    A mobile app called CAMMA would help family members caring for adults with chronic illnesses in Thailand feel less depressed and anxious through a culturally tailored mental health support program.

    NIH research Brigham and Women's Hospital · Boston, United States · NIH-11580924

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.