A system to analyze proteins in single cells more effectively
Official title: A Nanofluidic/Microfluidic System for Enhanced Low-Input and Single-Cell Proteomics
Funded at Fluidispec LLC · NIH-11008589 · Data updated 2026-11-12
This study is working on a new way to look at proteins in tiny amounts and in individual cells, which could help us understand how proteins change when diseases occur, leading to better tests and treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fluidispec LLC NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2024 |
| Project end | September 19, 2025 |
| Funding year | 2024 |
| Award (this year) | $350,000 |
| NIH project number | 1R41GM156144-01 |
| Project ID | NIH-11008589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diseases that involve significant changes in protein expression or modification.
✕Less likely to help
Patients with conditions unrelated to protein dysfunction or those who do not have a need for advanced proteomic analysis may not benefit from this research.
What this research studies
This research focuses on developing a novel microfluidic and nanofluidic system designed to enhance the analysis of proteins at low input levels and in single cells. By improving the methods for preparing and analyzing biological samples, the research aims to provide a clearer understanding of how proteins behave and change in response to diseases. This could lead to better diagnostic tools and more effective treatments by capturing the complexity of cellular functions and their alterations during disease progression.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in diagnosing and treating diseases by providing deeper insights into protein behavior at the cellular level.
How similar studies have gone: Previous research has shown promise in using microfluidic technologies for single-cell analysis, indicating that this approach could yield significant advancements in the field.
Where this research is happening
-
Fluidispec LLC
Philadelphia, United States Active
Researchers
- Principal investigator: Timperman, Aaron T — Fluidispec LLC
- Study coordinator: Timperman, Aaron T
Related research
Other NIH-funded projects on the same topics.
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A system for quickly analyzing proteins in individual cells
This study is working on a new way to quickly and easily analyze proteins from individual cells, which could help us understand diseases better and lead to more personalized treatments for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.