A system for targeted delivery of therapeutic cells using magnetic imaging.
Theranostic system for targeted, sustained-delivery with quantitative "hot spot" MPI of magnetic extracellular vesicles
This study is looking at a new way to help people with diabetes by creating an easy-to-inject system that delivers special healing cells right where they're needed in the body, while also letting doctors see how well the treatment is working in real-time.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10887519 on NIH RePORTER |
What this research studies
This research focuses on improving the delivery and effectiveness of therapeutic cells used in treating conditions like diabetes. It aims to develop a new injectable system that can deliver extracellular vesicles derived from stem cells directly to the target area in the body, while also allowing for real-time tracking of these vesicles using magnetic particle imaging. By enhancing the retention and distribution of these therapeutic agents, the research seeks to improve patient outcomes following cell transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with type 1 or advanced type 2 diabetes who are considering or have undergone pancreatic islet transplantation.
Not a fit: Patients who do not have diabetes or are not candidates for cell transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diabetes by ensuring that therapeutic cells remain functional and localized at the site of need.
How similar studies have performed: Similar approaches using extracellular vesicles for targeted therapy have shown promise in preliminary studies, indicating potential for success in this novel application.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Arifin, Dian Respati — Johns Hopkins University
- Study coordinator: Arifin, Dian Respati
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.