A system for quickly analyzing proteins in individual cells
Official title: A Microfluidic/Nanofluidic System for Rapid Single Cell Proteomics
Funded at Fluidispec LLC · NIH-10547040 · Data updated 2026-11-12
This study is working on a new way to quickly and easily analyze proteins from individual cells, which could help us understand diseases better and lead to more personalized treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fluidispec LLC NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $400,000 |
| NIH project number | 1R41GM148104-01 |
| Project ID | NIH-10547040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that exhibit significant cellular heterogeneity, such as cancer or autoimmune diseases.
✕Less likely to help
Patients with conditions that do not involve significant protein-level changes or cellular heterogeneity may not benefit from this research.
What this research studies
This research focuses on developing a new microfluidic and nanofluidic system that allows for the rapid analysis of proteins at the single-cell level. By improving the methods used to isolate and analyze proteins, this project aims to overcome the challenges posed by traditional techniques that often require larger cell populations. The innovative approach seeks to minimize sample loss and enhance the concentration of proteins, which is crucial for understanding the biological implications of cellular differences. Patients may benefit from insights gained into how diseases manifest at the protein level, potentially leading to more targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to more precise diagnostics and treatments for diseases by understanding protein behavior in individual cells.
How similar studies have gone: While single-cell proteomics is a growing field, this specific approach using microfluidic and nanofluidic systems represents a novel method that has not been widely tested.
Where this research is happening
-
Fluidispec LLC
Philadelphia, United States Active
Researchers
- Principal investigator: Timperman, Aaron T — Fluidispec LLC
- Study coordinator: Timperman, Aaron T
Related research
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A system to analyze proteins in single cells more effectively
This study is working on a new way to look at proteins in tiny amounts and in individual cells, which could help us understand how proteins change when diseases occur, leading to better tests and treatments for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.