A saliva test to detect head and neck cancer recurrence

Who could benefit from this research

What this research studies

This research aims to develop a non-invasive saliva test called HNKlear for the early detection of recurrence in squamous cell carcinoma of the head and neck (SCCHN). The test utilizes a panel of seven methylated microRNA biomarkers to provide timely and accurate results, addressing the limitations of current invasive and subjective detection methods. By analyzing saliva samples, the test seeks to improve patient outcomes through earlier intervention and monitoring. The research involves rigorous testing and validation to ensure the test's effectiveness and reliability.

Why it matters

Where this research is happening

• University of Colorado Denver
  Aurora, United States Active

Researchers

• Principal investigator: Lu, Shi-Long — University of Colorado Denver
• Study coordinator: Lu, Shi-Long

Related research

Other NIH-funded projects on the same topics.

• Combined Imaging and RNA Markers to Predict Head and Neck Cancer Recurrence

  A research project aims to use imaging and RNA data to better predict if head and neck cancer will come back, helping doctors tailor treatments for patients.

  NIH research Washington University · Saint Louis, United States · NIH-11607780

• Enhanced detection of head and neck cancer recurrence using automated EV isolation and vibrational spectroscopy

  A fast-track NIH grant is funding development of an automated test using blood or saliva samples to catch head and neck cancer recurrences early.

  NIH research Illumifydx, INC. · Broomfield, United States · NIH-11315161

• Using imaging and RNA analysis to predict cancer recurrence in the head and neck

  This study is looking for ways to predict if head and neck cancers might come back after treatment by using special imaging and tests on your RNA, so we can tailor your care and improve your chances of staying cancer-free.

  NIH research Washington University · Saint Louis, United States · NIH-10909477

• Keloid recurrence study using multi-omics in diverse patients

  A research effort will look at why keloids come back after surgery, especially in African American patients, using comprehensive molecular data from patient samples.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11641647

• Oral cancer recurrence predictor using tumor microbes and gene activity

  This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11591548

• Biomarker to guide treatment in head and neck cancer

  A biomarker test using tumor samples is being developed to predict recurrence risk in oral cancers and help tailor treatment.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11580855

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.