A saliva test to detect head and neck cancer recurrence
Validation of a saliva test using methylated microRNAs for head and neck cancer recurrence
This study is working on a simple saliva test called HNKlear that can help catch the return of head and neck cancer early, making it easier for patients to get the care they need without invasive procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10932401 on NIH RePORTER |
What this research studies
This research aims to develop a non-invasive saliva test called HNKlear for the early detection of recurrence in squamous cell carcinoma of the head and neck (SCCHN). The test utilizes a panel of seven methylated microRNA biomarkers to provide timely and accurate results, addressing the limitations of current invasive and subjective detection methods. By analyzing saliva samples, the test seeks to improve patient outcomes through earlier intervention and monitoring. The research involves rigorous testing and validation to ensure the test's effectiveness and reliability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with squamous cell carcinoma of the head and neck and are at risk for recurrence.
Not a fit: Patients who have not been diagnosed with head and neck cancer or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more accessible and cost-effective method for monitoring head and neck cancer recurrence, potentially improving survival rates.
How similar studies have performed: Previous studies have shown promising results with similar saliva-based tests, indicating a potential for success in this novel approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Lu, Shi-Long — University of Colorado Denver
- Study coordinator: Lu, Shi-Long
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.