A quick test for managing bleeding and strokes in patients on blood thinners.
Official title: 5-Minute Point-of-Care Anti-Factor Xa Test for Emergent Patient Management
Funded at DNA Medicine Institute · NIH-11005242 · Data updated 2026-11-12
This study is working on a quick test that can check your blood levels if you're taking certain blood thinners, helping doctors make fast decisions during emergencies like bleeding or strokes.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | DNA Medicine Institute NIH-funded |
| Lab location | 1 site (Cambridge, UNITED STATES) |
| Project start | September 10, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,022,908 |
| NIH project number | 1R44HL170817-01A1 |
| Project ID | NIH-11005242 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are currently taking direct oral anticoagulants and may experience bleeding or acute ischemic strokes.
✕Less likely to help
Patients not on direct oral anticoagulants or those with conditions unrelated to anticoagulation therapy may not benefit from this research.
What this research studies
This research aims to develop a rapid point-of-care test that measures anti-factor Xa levels and hemoglobin in patients who are on direct oral anticoagulants (DOACs). The test will provide results in just five minutes, allowing healthcare providers to make immediate decisions regarding treatment for bleeding or strokes. By using a specialized device and app, the test will help guide the use of andexanet alfa during emergencies, significantly improving patient management in acute situations. This innovative approach could lead to faster and more effective interventions for patients experiencing complications from anticoagulant therapy.
Why it matters
Potential benefit: If successful, this research could lead to quicker and more effective treatment for patients experiencing bleeding or strokes while on anticoagulant medications.
How similar studies have gone: Other research has shown success with rapid point-of-care testing in emergency settings, indicating a promising approach for this novel test.
Where this research is happening
-
DNA Medicine Institute
Cambridge, United States Active
Researchers
- Principal investigator: Chan, Eugene Yan-Ho — DNA Medicine Institute
- Study coordinator: Chan, Eugene Yan-Ho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.