A protein that helps gut cells make protective mucus
TVP23B and Golgi Mediated Control of Intestinal Secretory Cells
This work studies how the Golgi protein TVP23B keeps gut barrier cells healthy for people with inflammatory bowel conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11251310 on NIH RePORTER |
What this research studies
Scientists use mice missing the TVP23B gene to learn why mucus and antimicrobial peptides fall and bacteria come closer to the gut lining. They examine the function of goblet and Paneth cells, analyze Golgi-dependent glycosylation of mucins, and test responses to chemical injury and bacterial infection. The team also studies how TVP23B partners with the Golgi protein YIPF6 and how loss of these proteins changes Golgi enzyme content. The experiments aim to link those molecular changes to weaker intestinal barriers and colitis susceptibility.
Who could benefit from this research
Good fit: People with inflammatory bowel disease (ulcerative colitis or Crohn's disease) or those with recurrent infectious colitis would be most likely to benefit from these findings.
Not a fit: People without gastrointestinal disease or whose conditions are driven by non-mucus-related causes are unlikely to receive direct benefit from this specific work.
Why it matters
Potential benefit: If successful, this work could point to new ways to strengthen the gut mucus barrier and reduce infections or inflammation in people with colitis.
How similar studies have performed: Prior mouse genetics and mucin glycosylation studies have linked Golgi function to colitis risk, but the specific role of TVP23B and its partnership with YIPF6 is newly described.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Turer, Emre Erol — Ut Southwestern Medical Center
- Study coordinator: Turer, Emre Erol
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.