A procedure using imaging to prevent breast cancer by targeting mammary cells.
Image-Guided Intraductal Ablative Procedure for Primary Prevention of Breast Cancer
This study is looking at a new way to help prevent breast cancer by using a special procedure that injects a safe solution into the milk ducts to target and destroy certain cells, offering a gentler option for women at moderate to low risk who want to avoid more drastic surgeries like mastectomy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10992666 on NIH RePORTER |
What this research studies
This research investigates a novel approach to prevent breast cancer by using an image-guided intraductal ablative procedure. It focuses on injecting a refined ethanol solution into the mammary ducts to locally destroy mammary epithelial cells, which may reduce the risk of developing breast cancer. The study aims to provide a less invasive alternative to prophylactic mastectomy, particularly for women at moderate to low risk. The methodology includes monitoring the procedure's effectiveness using advanced imaging techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research are women at moderate to low risk of developing breast cancer, particularly those with BRCA1/2 gene mutations.
Not a fit: Patients who have already been diagnosed with breast cancer or those who are at very high risk requiring immediate surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could offer a new, less invasive option for breast cancer prevention, reducing the need for more aggressive surgeries.
How similar studies have performed: Previous studies have shown promising results with similar ablative techniques in animal models, suggesting potential for success in human applications.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Sempere, Lorenzo — Michigan State University
- Study coordinator: Sempere, Lorenzo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.