A portable and easy-to-use device for administering Naloxone to reverse opioid overdoses
Official title: A Rugged, Reliable, Portable, Safe, and Simple Naloxone HCl Auto-Injector forLife-Saving Treatment of Opioid Overdose
Funded at Pirouette Medical · NIH-10764158 · Data updated 2026-11-12
This study is working on a simple and easy-to-use auto-injector for Naloxone, a lifesaving medicine that can help people who are having an opioid overdose, so that anyone nearby can quickly help in an emergency.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pirouette Medical NIH-funded |
| Lab location | 1 site (Portsmouth, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $326,500 |
| NIH project number | 1R43DA059474-01 |
| Project ID | NIH-10764158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk of opioid overdose, their family members, and bystanders who may witness an overdose.
✕Less likely to help
Patients who are not at risk of opioid overdose or do not have access to the auto-injector may not benefit from this research.
What this research studies
This research focuses on developing a user-friendly auto-injector for Naloxone, a medication that can quickly reverse opioid overdoses. The device is designed for use by untrained bystanders in emergency situations, ensuring that it is safe, reliable, and effective. By simplifying the administration process, the goal is to increase the likelihood of timely intervention during an overdose, potentially saving lives. The project builds on previous successful designs to create a robust and portable solution for opioid overdose emergencies.
Why it matters
Potential benefit: If successful, this research could significantly reduce opioid overdose fatalities by making Naloxone more accessible and easier to administer in critical situations.
How similar studies have gone: Previous research has shown that auto-injectors for emergency medications, like epinephrine, have been successful, indicating a promising potential for this approach with Naloxone.
Where this research is happening
-
Pirouette Medical
Portsmouth, United States Active
Researchers
- Principal investigator: Cullinane, Conor R — Pirouette Medical
- Study coordinator: Cullinane, Conor R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.