A platform to test drugs for a serious intestinal disease in premature infants
Neonatal gut-on-a-chip platform for high content drug testing and precision medicine
This study is creating a special model that mimics the intestines of premature babies with a serious condition called necrotizing enterocolitis (NEC) to help researchers understand the disease better and find new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10889136 on NIH RePORTER |
What this research studies
This research investigates a unique intestine-on-a-chip model designed to mimic the intestinal environment of premature infants suffering from necrotizing enterocolitis (NEC). By using a combination of intestinal organoids, human endothelial cells, and patient-derived microbiota, the study aims to recreate the disease's critical features in a controlled laboratory setting. The goal is to gain insights into the disease's mechanisms and evaluate potential therapeutic options through advanced multi-omic approaches. This innovative model allows researchers to better understand NEC and test the effectiveness of new drugs before they are used in clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants at risk of developing necrotizing enterocolitis.
Not a fit: Patients who are not premature or do not have a risk of necrotizing enterocolitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for necrotizing enterocolitis, improving outcomes for premature infants.
How similar studies have performed: Other research has shown promise using similar organ-on-a-chip technologies, indicating potential for success in this novel approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Good, Misty L — Univ of North Carolina Chapel Hill
- Study coordinator: Good, Misty L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.