A platform to study how RNA interacts with proteins in cells
An RNA editing platform to investigate the dynamic RNA interactome
This study is exploring how RNA molecules connect with proteins to help control gene activity, using a new tool called TRIBE-ID, which could eventually lead to better treatments for different diseases by understanding these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-10981065 on NIH RePORTER |
What this research studies
This research focuses on understanding how RNA molecules bind to proteins, which is crucial for regulating gene expression. By developing a new RNA editing platform called TRIBE-ID, the researchers aim to investigate these interactions in a more efficient and detailed manner. The approach will allow for the profiling of RNA substrates and the study of how small molecules can influence RNA-protein interactions. This could lead to new therapeutic strategies for various diseases by targeting these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to RNA-binding protein dysfunction, such as certain neurodegenerative diseases or cancers.
Not a fit: Patients with conditions unrelated to RNA-protein interactions or those not affected by RNA-binding protein dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases by improving our understanding of RNA-protein interactions.
How similar studies have performed: Other research has shown promise in targeting RNA-protein interactions, indicating that this approach could be a valuable addition to existing therapeutic strategies.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Kleiner, Ralph Elliot — Princeton University
- Study coordinator: Kleiner, Ralph Elliot
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.