A platform to study how RNA interacts with proteins in cells
Official title: An RNA editing platform to investigate the dynamic RNA interactome
Funded at Princeton University · NIH-10981065 · Data updated 2026-11-12
This study is exploring how RNA molecules connect with proteins to help control gene activity, using a new tool called TRIBE-ID, which could eventually lead to better treatments for different diseases by understanding these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | September 21, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $328,000 |
| NIH project number | 1R01GM152748-01A1 |
| Project ID | NIH-10981065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by conditions related to RNA-binding protein dysfunction, such as certain neurodegenerative diseases or cancers.
✕Less likely to help
Patients with conditions unrelated to RNA-protein interactions or those not affected by RNA-binding protein dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding how RNA molecules bind to proteins, which is crucial for regulating gene expression. By developing a new RNA editing platform called TRIBE-ID, the researchers aim to investigate these interactions in a more efficient and detailed manner. The approach will allow for the profiling of RNA substrates and the study of how small molecules can influence RNA-protein interactions. This could lead to new therapeutic strategies for various diseases by targeting these interactions.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases by improving our understanding of RNA-protein interactions.
How similar studies have gone: Other research has shown promise in targeting RNA-protein interactions, indicating that this approach could be a valuable addition to existing therapeutic strategies.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Kleiner, Ralph Elliot — Princeton University
- Study coordinator: Kleiner, Ralph Elliot
Related research
Other NIH-funded projects on the same topics.
-
How neuropeptides could influence aging and Alzheimer’s risk
Researchers at Princeton are studying whether changing brain signaling chemicals called neuropeptides can extend healthy aging and reduce Alzheimer’s-related brain changes, with a focus on people at risk for Alzheimer’s disease dementia.
-
Sleep and aging brain resilience in a short-lived vertebrate model
A young-aged-friendly project explores how sleep quality affects brain health during aging, using a tiny, fast-lived fish model to understand Alzheimer’s-related changes.
-
How hepatitis C adapts to other species to help develop vaccines
Researchers are making a mouse-friendly version of hepatitis C so scientists can better test vaccines and understand the virus for people living with or at risk of hepatitis C.
-
Mapping how cells push and pull in living tissues
A science project at Princeton aims to map and control the forces between cells in 3D tissues to better understand cancer, development, and healing, with potential benefits for patients in the future.
-
Understanding how brain signals give rise to thinking using brain-wide recordings
Researchers at Princeton are developing new brain theories and computer tools to understand how complex neural signals relate to thinking and behavior.
-
Cancer metabolism revealed through mass spectrometry and isotope tracing
A scientist team at Princeton will study how cancer cells use nutrients by analyzing metabolites with advanced mass spectrometry and labeled tracers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.