A platform to improve breast cancer screening based on individual risk factors
Official title: WISDOM: A platform to optimize subtype-specific screening and prevention
Funded at University of California, San Francisco · NIH-10935787 · Data updated 2026-11-12
This study is looking to improve breast cancer screening by personalizing it based on each woman's unique risk factors, like her medical history and genetics, to see if this approach is safer and more effective than the usual methods.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 11, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $3,537,456 |
| NIH project number | 1P01CA281826-01A1 |
| Project ID | NIH-10935787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who are at risk for breast cancer based on various factors such as family history, genetic markers, and breast density.
✕Less likely to help
Patients who do not have risk factors for breast cancer or those who have already been diagnosed with breast cancer may not benefit from this research.
What this research studies
This research focuses on optimizing breast cancer screening by tailoring it to individual risk factors, including clinical history, race/ethnicity, breast density, and genetic predispositions. By enrolling 45,000 women, the study aims to determine if a risk-based approach is safer and more effective than traditional methods. The research will utilize advanced models to predict the specific type of breast cancer a woman may develop, allowing for personalized screening and prevention strategies. The goal is to enhance the overall effectiveness of breast cancer screening while reducing unnecessary procedures and improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized breast cancer screening, ultimately reducing mortality and improving quality of life for women at risk.
How similar studies have gone: Other research has shown promising results with risk-based screening approaches, indicating potential for significant advancements in breast cancer detection and prevention.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Esserman, Laura J — University of California, San Francisco
- Study coordinator: Esserman, Laura J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.