A Personalized Methadone Dosing System
Official title: Methadone Dosing System (MDS)
Funded at Cari Health, INC. · NIH-11324767 · Data updated 2026-11-12
This project is creating a new way to figure out the right methadone dose for each person to help them overcome opioid addiction more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cari Health, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,447,789 |
| NIH project number | 4U44DA059627-02 |
| Project ID | NIH-11324767 on NIH RePORTER |
Who could benefit from this research
✓Could help
This approach is designed for individuals seeking treatment for opioid use disorder who are prescribed methadone.
✕Less likely to help
Patients not undergoing methadone maintenance treatment for opioid use disorder would not directly benefit from this specific dosing system.
What this research studies
Many people trying to stop opioid use face tough withdrawal symptoms, which can make it hard to continue treatment. Methadone is a helpful medicine, but how well it works can vary a lot from person to person due to differences in their body's metabolism. This project aims to develop a new, science-based approach to methadone dosing that considers your unique metabolism. The goal is to find the perfect dose for you, reducing side effects and preventing withdrawal symptoms, to make your journey to recovery smoother.
Why it matters
Potential benefit: If successful, this system could lead to more effective and personalized methadone treatment, helping more patients overcome opioid addiction with fewer withdrawal symptoms and side effects.
How similar studies have gone: Current methadone dosing often follows general guidelines, so this project introduces a novel, personalized approach based on individual metabolism.
Where this research is happening
-
Cari Health, INC.
San Diego, United States Active
Researchers
- Principal investigator: Schmidle, Patrik — Cari Health, INC.
- Study coordinator: Schmidle, Patrik
Related research
Other NIH-funded projects on the same topics.
-
Methadone Dosing System to personalize opioid treatment
A new, science‑based dosing approach aims to tailor methadone treatment for people with opioid use disorder to reduce withdrawal and improve retention.
-
Improving methadone dosing for opioid addiction treatment
This study is working on a new way to personalize methadone treatment for people recovering from opioid addiction, so that the dose fits each person's unique metabolism, helping them feel better and stay in treatment longer.
-
A system to improve methadone treatment for opioid use disorder
This study is looking at a new way to help people with opioid use disorder by making it easier for them to get their methadone treatment, especially for those who have a hard time going to daily appointments, so they can feel better and have more freedom in their lives.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.