A non-invasive method to analyze gut health for better treatment of gastrointestinal disorders
Official title: Non-invasive exfoliome platform to accelerate treatment for gastrointestinal disorders
Funded at Foli Bio INC. · NIH-11008414 · Data updated 2026-11-12
This study is looking at a new, gentle way to check the health of your gut by analyzing tiny bits of DNA and RNA found in your stool, which could help doctors understand and treat inflammatory bowel diseases like Crohn's and ulcerative colitis better.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Foli Bio INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $292,375 |
| NIH project number | 1R43DK141382-01 |
| Project ID | NIH-11008414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are diagnosed with inflammatory bowel diseases such as Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients with gastrointestinal disorders who are under 21 years old or those who do not have inflammatory bowel diseases may not benefit from this research.
What this research studies
This research focuses on developing a non-invasive platform that analyzes the exfoliome, which consists of RNA and DNA shed from intestinal cells into stool. By profiling these biological markers, the research aims to better understand the molecular processes involved in inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The approach seeks to identify specific gene expression patterns that can inform more effective, personalized treatment strategies for patients suffering from these chronic gastrointestinal disorders. This method allows for continuous monitoring of gut health without the need for invasive procedures.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with gastrointestinal disorders, improving their quality of life.
How similar studies have gone: While the approach of using the exfoliome for gastrointestinal profiling is innovative, similar multi-omics strategies have shown promise in other areas of medical research, indicating potential for success.
Where this research is happening
-
Foli Bio INC.
New York, United States Active
Researchers
- Principal investigator: Huang, Yiming — Foli Bio INC.
- Study coordinator: Huang, Yiming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.