A New Way to Understand Important Cholesterol Particles (HDL)
Development of a Novel Technology for Preparative Fractionation and Characterization of Lipoprotein Particles
This project is creating a new tool to better understand high-density lipoprotein (HDL) particles, which are important for protecting against many diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11166678 on NIH RePORTER |
What this research studies
High-density lipoproteins, or HDL, are often called "good cholesterol" because they are strongly linked to long, healthy lives and protect against conditions like heart disease, brain disorders, and infections. Despite knowing their importance for over 50 years, it's been hard to develop treatments that improve HDL function because these particles are very complex and difficult to study. This project is building a special instrument that can precisely measure the size and number of HDL particles and keep them intact for detailed analysis. This new technology will help scientists overcome a major hurdle in understanding HDL, paving the way for future discoveries.
Who could benefit from this research
Good fit: Patients who could potentially benefit are those with conditions like cardiovascular disease, neurodegeneration, or acute infections, as future treatments might arise from this foundational research.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not receive benefit from this foundational technology development.
Why it matters
Potential benefit: If successful, this technology could unlock new insights into how HDL works, leading to better ways to prevent and treat a wide range of diseases.
How similar studies have performed: The project aims to solve a critical problem due to a lack of existing technologies, suggesting this approach is novel and untested in its specific application.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Zivkovic, Angela M — University of California at Davis
- Study coordinator: Zivkovic, Angela M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.