A new way to study gene regulation during development
A novel method to characterize cis-regulatory complexes during development
['FUNDING_R21'] · CITY COLLEGE OF NEW YORK · NIH-10706598
This study is looking at how our genes are controlled as we grow, by figuring out which proteins work with certain parts of our DNA to help genes turn on and off, and it’s for anyone interested in understanding more about how our bodies develop and what might go wrong in diseases.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CITY COLLEGE OF NEW YORK (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10706598 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how genes are regulated during the development of multicellular organisms. It aims to identify the proteins that interact with specific DNA sequences known as cis-regulatory elements, which play a crucial role in gene expression. By using a method called electroporation, researchers will introduce DNA into cells to detect these interactions and evaluate the sequence requirements for effective gene regulation. This approach could provide valuable insights into the mechanisms of development and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or developmental issues that may be linked to gene regulation.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have a genetic component to their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene regulation, which may inform new treatments for developmental disorders and diseases linked to gene expression.
How similar studies have performed: While the approach of using electroporation for studying gene regulation is established, the specific application to cis-regulatory complexes during development is relatively novel and has not been extensively tested.
Where this research is happening
NEW YORK, UNITED STATES
- CITY COLLEGE OF NEW YORK — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EMERSON, MARK M — CITY COLLEGE OF NEW YORK
- Study coordinator: EMERSON, MARK M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.