A New Way to Prevent Blood Clots in Catheters
Official title: Contact Pathway Inhibitor to Prevent Catheter-Related Thrombosis
Funded at Aronora, INC. · NIH-11170174 · Data updated 2026-11-12
This project is developing a new medicine to help prevent blood clots and inflammation in central venous catheters, especially for patients who need these catheters for medical treatments.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Aronora, INC. NIH-funded |
| Lab location | 1 site (Portland, UNITED STATES) |
| Project start | June 15, 2024 |
| Project end | June 14, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,069,527 |
| NIH project number | 4R44HL170881-02 |
| Project ID | NIH-11170174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who frequently use central venous catheters for medical treatments, particularly those with conditions like cancer who are at higher risk for blood clots, would be ideal candidates.
✕Less likely to help
Patients who do not require central venous catheters or are not at risk for catheter-related blood clots would not directly benefit from this specific treatment.
What this research studies
Central venous catheters (CVCs), such as PICC lines or implanted ports, are essential for many medical treatments but can lead to complications like blood clots and infections. These catheter-related clots can cause problems ranging from device failure to more serious issues like blocked blood vessels. Current clot-preventing medicines are often not suitable for all patients, particularly those with cancer, due to risks of bleeding or limited effectiveness. This research aims to create a safer and more effective medicine that specifically targets the body's clotting and inflammation pathways to prevent these catheter-related clots.
Why it matters
Potential benefit: If successful, this new medicine could significantly reduce the risk of dangerous blood clots and inflammation for patients relying on central venous catheters, making their treatments safer and more effective.
How similar studies have gone: A small phase 2 clinical study has already been conducted in cancer patients with CVCs, suggesting some initial promising results for this approach.
Where this research is happening
-
Aronora, INC.
Portland, United States Active
Researchers
- Principal investigator: Lorentz, Christina U — Aronora, INC.
- Study coordinator: Lorentz, Christina U
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.