A new way to help people quit smoking using a digital nicotine therapy.
Official title: Assessment of a Digitally Controlled Aerosolized Nicotine Replacement Therapy
Funded at Predictably Human, INC. · NIH-11287903 · Data updated 2026-11-12
This study is testing a new product called 'NoMore,' which is a safe, digital spray that helps people quit smoking by giving them nicotine without the harmful stuff in cigarettes, making it easier to stop smoking for good.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Predictably Human, INC. NIH-funded |
| Lab location | 1 site (Darien, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,118,284 |
| NIH project number | 4R42DA060773-02 |
| Project ID | NIH-11287903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult smokers who are motivated to quit and have previously struggled with cessation methods.
✕Less likely to help
Patients who do not smoke or are not interested in quitting smoking may not benefit from this research.
What this research studies
This research focuses on developing 'NoMore,' a digitally controlled aerosolized nicotine replacement therapy designed to help individuals quit smoking. Unlike traditional methods, NoMore delivers nicotine without harmful constituents, mimicking the experience of smoking to ease the transition away from cigarettes. The therapy aims to gradually reduce nicotine dependence after quitting, potentially doubling the effectiveness of current cessation medications. Patients will be monitored for their smoking habits and biochemical markers to assess the therapy's success.
Why it matters
Potential benefit: If successful, this research could significantly improve smoking cessation rates and reduce the health risks associated with smoking.
How similar studies have gone: Preliminary studies have shown promising results for similar nicotine aerosol therapies, indicating a potential for success with this novel approach.
Where this research is happening
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Predictably Human, INC.
Darien, United States Active
Researchers
- Principal investigator: Davis, James M — Predictably Human, INC.
- Study coordinator: Davis, James M
Related research
Other NIH-funded projects on the same topics.
-
NoMore: a digitally controlled nicotine inhaler to help people quit smoking
A new prescription aerosol nicotine replacement device called NoMore aims to help people quit smoking by delivering nicotine in a controlled, digital way and tapering off over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.