A new way for cells to survive after near-death.
Official title: Anastasis: A Novel Cell Survival Mechanism
Funded at Johns Hopkins University · NIH-10933429 · Data updated 2026-11-12
This study is looking at a new way that cells can bounce back from near-death, which could help us find better treatments for heart failure and brain injuries, while also understanding how cancer cells might resist treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $409,375 |
| NIH project number | 5R35GM150835-02 |
| Project ID | NIH-10933429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with heart failure, brain injuries, or those undergoing cancer treatment.
✕Less likely to help
Patients with conditions unrelated to cell death or survival mechanisms may not benefit from this research.
What this research studies
This research investigates a newly discovered mechanism called anastasis, which allows cells that are on the verge of dying to recover and survive. The study explores how this process works in various types of cells, including those from humans and animals, and its potential implications for treating conditions like heart failure and brain injuries. By understanding how anastasis functions, researchers aim to find ways to enhance this survival mechanism in critical cells, while also considering its role in cancer cell resistance to therapies. The research employs advanced techniques to track and analyze cell behavior during this recovery process.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery from heart failure and brain injuries, as well as strategies to combat cancer recurrence.
How similar studies have gone: While the concept of anastasis is relatively novel, preliminary findings suggest that similar mechanisms of cell survival have shown promise in other studies, indicating potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Tang, Ho Lam — Johns Hopkins University
- Study coordinator: Tang, Ho Lam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.